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color transformed images of GABAA receptor delta subunit expression in virgin (left panels) and pregnant (right panels) wild type mice.


 

 



maguire lab

Understanding the regulation of GABAA receptors (GABAARs), which mediate the majority of inhibitory synaptic transmission in the central nervous system (CNS), will help us elucidate the pathophysiology of numerous neurological and neuropsychiatric disorders, ranging from epilepsy to postpartum depression.

Stress is a common trigger for many disorders, likely due to the impact of stress hormones on neuronal excitability. The major output of the stress response, namely paraventricular neurons (PVN) of the hypothalamus, are under GABAergic control. The goal of the Maguire lab is to determine the nature of GABAAR regulation of the PVN and how dysfunction may play a role in the pathophysiology of neurological and neuropsychiatric disorders.

   

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spontaneous firing of a PVN neuron.
   
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