full list of publications on Google Scholar: click here
Recent Publications
Antonoudiou P, Teboul E, Amaya KA, Stone BT, Dorst KE, Maguire JL. Biased information routing through the basolateral amygdala, altered valence processing, and impaired affective states associated with psychiatric illnesses. Biol Psychiatry. 2024 Oct 10;. doi: 10.1016/j.biopsych.2024.10.003. [Epub ahead of print] Review. PubMed PMID: 39395471; NIHMSID:NIHMS2028762.
Maguire J & Mennerick S (2024) Neurosteroids: mechanistic considerations and clinical prospects. Neuropsychopharmacology. volume 49, pages73–82.
Antonoudiou P, Stone BT, Colmers PLW, Evans-Strong A, Teboul E, Walton NL, Weiss GL, Maguire J. Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes. Cell Rep. 2024 Jul 23;43(7):114489. doi: 10.1016/j.celrep.2024.114489. Epub 2024 Jul 9. PubMed PMID: 38990724; PubMed Central PMCID: PMC11330675.
Bradly T. Stone, Pantelis Antonoudiou, Eric Teboul, Garrett Scarpa, Grant Weiss, Jamie L. Maguire (2023) Early life stress impairs VTA coordination of BLA network and behavioral states. bioRxiv. https://doi.org/10.1101/2023.09.16.558081.
Amaya KA, Teboul E, Weiss GL, Antonoudiou P, Maguire JL. Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors. Curr Biol. 2024 Apr 8;34(7):1561-1568.e4. doi: 10.1016/j.cub.2024.02.041. Epub 2024 Mar 12. PubMed PMID: 38479389; PubMed Central PMCID: PMC11003843.
Evans-Strong A, Walton N, Blandino K, Roper ATC, Donaldson ST, Lewis M, Maguire J. Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis. J Neuroendocrinol. 2024 Apr;36(4):e13378. doi: 10.1111/jne.13378. Epub 2024 Mar 14. PubMed PMID: 38482748; PubMed Central PMCID: PMC11091913.
Walton N., Antonoudiou P., Barros L., DiLeo A., Gabby J., Howard S., Paracha R., Sanchez E., Weiss G., Kong D., Maguire J (2023) Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2023.01.022.
Kirstie Cumming and Jamie Maguire (2022) Interneurons direct circuit-specific flow of information to communicate stressful experiences. Neuron. Volume 110, Issue 6, 911-913.
Epilepsy
Hooper A, Paracha R, Maguire J. Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy & Behavior. 2017. 78:124-133.
Sivakumaran S, Maguire J. Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus. Epilepsia. 2016 Feb;57(2):222-32. doi: 10.1111/epi.13270. PubMed PMID: 26659482.
Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci. 2015 May 27;35(21):8291-6. doi: 10.1523/JNEUROSCI.5205-14.2015. PubMed PMID: 26019342; PubMed Central PMCID: PMC4444547.
O'Toole KK, Hooper A, Wakefield S, Maguire J. Seizure-induced disinhibition of the HPA axis increases seizure susceptibility. Epilepsy Res. 2014 Jan;108(1):29-43. doi: 10.1016/j.eplepsyres.2013.10.013. PubMed PMID: 24225328; PubMed Central PMCID: PMC3872265.
Lee V, Maguire J. Impact of inhibitory constraint of interneurons on neuronal excitability. J Neurophysiol. 2013 Dec;110(11):2520-35. doi: 10.1152/jn.00047.2013. PubMed PMID: 24027099; PubMed Central PMCID: PMC3882765.
Depression/ Postpartum Depression
Antonoudiou P., Colmers P., Walton N., Weiss G., Smith A., Nguyen D, Lewis M., Quirk M., Barros L., Melon L., Maguire J. (2021) Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala. Biological Psychiatry. Feb 1;91(3):283-293. https://doi.org/10.1016/j.biopsych.2021.07.017.
Melón L, Hammond R, Lewis M, Maguire J. A Novel, Synthetic, Neuroactive Steroid Is Effective at Decreasing Depression-Like Behaviors and Improving Maternal Care in Preclinical Models of Postpartum Depression. Frontiers in Endocrinol. 2018; 9: 703.
Melón L, Hooper A, Yang X, Moss S, Maguire J. Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology. 2017. 90: 182-193.
Maguire J, Mody I. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plast. 2016;2016:2762518. doi: 10.1155/2016/2762518. PubMed PMID: 26819762; PubMed Central PMCID: PMC4706939.
Maguire J, Ferando I, Simonsen C, Mody I. Excitability changes related to GABAA receptor plasticity during pregnancy. J Neurosci. 2009 Jul 29;29(30):9592-601. doi: 10.1523/JNEUROSCI.2162-09.2009. PubMed PMID: 19641122; PubMed Central PMCID: PMC2875247.
Maguire J, Mody I. Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci. 2007 Feb 28;27(9):2155-62. PubMed PMID: 17329412.
Maguire JL, Stell BM, Rafizadeh M, Mody I. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci. 2005 Jun;8(6):797-804. PubMed PMID: 15895085.
Fear/Anxiety
Xin Fu, Eric Teboul, Grant L. Weiss, Pantelis Antonoudiou, Chandrashekhar D. Borkar, Jonathan P. Fadok, Jamie Maguire & Jeffrey G. Tasker. (2022) Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice. Nature Communications. volume 13, Article number: 1290. https://rdcu.be/cIKKJ
Ozawa M, Davis P, Ni J, Maguire J, Papouin T, Reijmers L (2020) Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction. Nature Communications. 11, Article number: 4358
Davis P, Zaki Y, Maguire J, Reijmers L. Cellular and oscillatory substrates of fear extinction learning. Nature Neuroscience. 2017. 20(11):1624-1633. PMID: 28967909.
Stress
Lee V, MacKenzie G, Hooper A, Maguire J. Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory. Hippocampus. 2016 Oct;26(10):1276-90. doi: 10.1002/hipo.22604. PubMed PMID: 27163381; PubMed Central PMCID: PMC5030140.
Hooper A, Maguire J. Characterization of a novel subtype of hippocampal interneurons that express corticotropin-releasing hormone. Hippocampus. 2016 Jan;26(1):41-53. doi: 10.1002/hipo.22487. PubMed PMID: 26135556.
MacKenzie G, Maguire J. Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. Epilepsy Res. 2015 Jan;109:13-27. doi: 10.1016/j.eplepsyres.2014.10.003. PubMed PMID: 25524838; PubMed Central PMCID: PMC4272449.
Lee V, Sarkar J, Maguire J. Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors. Psychoneuroendocrinology. 2014 Mar;41:75-88. doi: 10.1016/j.psyneuen.2013.12.011. PubMed PMID: 24495609; PubMed Central PMCID: PMC3947777.
Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 2011 Dec 14;31(50):18198-210. doi: 10.1523/JNEUROSCI.2560-11.2011. PubMed PMID: 22171026; PubMed Central PMCID: PMC3272883.
Alcohol Use Disorders
DiLeo A, Antonoudiou, P, Ha S, and Maguire J (2022) Sex differences in the alcohol-mediated modulation of BLA network states. eNeuro 2022; 10.1523/ENEURO.0010-22.2022
Darnieder LM, Melón LC, Do T, Walton NL, Miczek KA, Maguire JL. Female-specific decreases in alcohol binge-like drinking resulting from GABA A receptor delta-subunit knockdown in the VTA. Scientific reports 9 (1), 8102.
Melón L, Nasman J, St. John A, Mbonu K, Maguire J. Interneuronal δ-GABAA receptors regulate binge drinking and are necessary for the behavioral effects of early withdrawal. 2019. Neuropsychopharmacology. 44: 425–434